Hormonal responsiveness in the Trier Social Stress Test and the dexamethasone‐corticotropin releasing hormone test in healthy individuals

A number of different laboratory procedures investigate the hormonal response in a standardized pharmacological challenge test (dexamethasone-corticotropin releasing hormone; DEX-CRH) or psychosocial stress induction on hypothalamic–pituitary–adrenocortical axis by Trier Social Stress Test (TSST). However, magnitude related to stressors and interaction responsiveness between two tests is still unclear. Fifty-two participants underwent both DEX-CRH TSST separate days. The cortisol plasma adrenocorticotropic hormone (ACTH) release were assessed before after tests. For specification conditions, subgroups high- low-cortisol responders formed. healthy showed substantial increase ACTH concentration This was 3 times greater than test. High demonstrated higher factor reactivity ratio (TSST/DEX-CRH test). Psychosocial as induced associated with significantly compared test, even though displayed no differences. Our findings indicate an regard patterns.